In the non-sensory supporting cells of the inner ear, key genes required for conversion to sensory cells are shut off through a process known as epigenetic silencing. By studying how the genes are shut off, we begin to understand how we might turn them back on to regenerate hearing.
Driven by Data and Collaboration
The collaborative spirit of our Hearing Restoration Project consortium is especially evident as we work together to complete a publication describing our analysis of hair cell gene expression.
HHF Is 65 This Year!
More funding and more time leads to more ambitious experimental plans, additional data collected, and a stronger footing for subsequent research and research funding.
Bellucci Symposium on Hearing Research May 19
We’re happy to see so many familiar faces who will be presenting at a one-day hybrid research symposium hosted by Creighton University in Omaha, Nebraska. This event will be presented by Creighton’s Translational Hearing Center and is free and open to the public.
Balance Problems? Loud Sounds Could Be a Cause
Have you ever felt dizzy, nauseous, or unsteady on your feet after leaving a loud concert? That could be the balance organ inside your inner ear reacting to the loud sounds.
Highlights From the Hearing Restoration Project
Here are highlights of recent accomplishments, including demonstrating that a cocktail of three factors can promote conversion of nonsensory cells into hair cells in the mouse model.
Inner Ear Cell Types Between Fish and Mammals Show Similarities
The similarities of inner ear cell type composition between fish and mammals validate the zebrafish as a relevant model for understanding inner ear-specific hair cell function and regeneration.
ARO MidWinter Meeting in Person Again
The annual ARO MidWinter Meeting is the preeminent conference for scientists and clinicians conducting research in the hearing and balance fields. The 46th meeting just concluded after five days in Orlando, Florida—the first in-person conference since late January 2020.
Our Impact in 2022, Thanks to You
Molecular Barriers to Overcome for Hair Cell Regeneration in the Adult Mouse Cochlea
The research suggests that reprogramming with multiple transcription factors is better able to access the hair cell differentiation gene regulatory network, but that additional interventions may be necessary to produce mature and fully functional hair cells.