Cynthia Grimsley-Myers, Ph.D.
Meet the Researcher
Cynthia Grimsley-Myers, Ph.D. received her Ph.D. in Pharmacology from the University of Virginia in 2005.
She then conducted post-doctoral research in the laboratory of Dr. Xiaowei Lu at the University of Virginia where she studied signaling mechanisms underlying inner ear development and hair cell polarization. She is currently a research instructor at Emory University where she investigates cochlear development.
Dr. Grimsley-Myers is funded by HHF's New York Council.
The Research
Emory University
The essential role of URB, a novel secreted protein, in cochlear development and planar cell polarity signaling
Hearing depends on highly structured hair bundles in the cochlea properly oriented towards the lateral border of the cochlear duct. Abnormalities in this hair bundle structure or its orientation results in hearing loss, for example in the hereditary disorder Usher syndrome. However, the molecular mechanisms that build the polarized structure of individual hair cells remain poorly understood. Our research focuses on the role of a novel secreted protein, URB, in hair bundle morphogenesis and cochlear development. In particular, we are testing whether URB functions as part of a Planar Cell Polarity (PCP) signaling pathway, a highly conserved pathway of widespread biological interest. We are also investigating possible links between URB and the Usher syndrome network of proteins. We hope that defining these roles for URB in bundle morphogenesis will help in the design of rational therapies for the treatment of Usher syndrome and other forms of hereditary hearing loss in the future.
Research area: Auditory Development; Auditory Physiology; Fundamental Auditory Research; Usher Syndrome
Long-term goal of research: To understand the specific cellular and molecular functions of URB in hair bundle morphogenesis and planar cell polarity (PCP) signaling and how mutations in URB/PCP signaling contribute to hearing loss.