What Does It Mean To Be 4-Star Charity?

By Sloan Blanton

The nonprofit sector is growing, with more and more organizations and foundations emerging daily. However, they are not all managed or held to the same standard. Because of this, donors want to be ensured their philanthropic dollars are being utilized and allocated properly. They are requesting higher accountability and transparency from the organizations they support.

Such donors look for third-party accreditation that their dollars are being maximized. Charity Navigator is America's most-utilized independent evaluator of charities in the competitive philanthropic marketplace, championing efficient, successful, open and ethical charities. By celebrating top charities, Charity Navigator provides the public with useful information needed to provide donors with confidence in their charitable choices.

Charity Navigator has rated Hearing Health Foundation (HHF) with 4 out of 4 stars, the highest possible rating. This indicates that HHF adheres to sound governance, accountability, transparency, and fiscal management, minimizing the organization’s chance of engaging in fiscally irresponsible activities. This rating from Charity Navigator also illustrates how HHF pursues its mission to prevent and cure hearing loss and tinnitus while promoting hearing health in a financially responsible way.

Hearing Health Foundation’s 4-star rating from Charity Navigator differentiates HHF from its peers, and assures the public it is worthy of their trust. "Donors have a choice as to where they invest their philanthropic dollars. We strive to make the greatest impact with every contribution to HHF and are honored to be recognized for our efforts by Charity Navigator, America's premier charity evaluator," said Claire Schultz, HHF’s chief executive officer.

Forbes, Business Week, and Kiplinger's Financial Magazine, among others, applaud Charity Navigator's unique method of applying data-driven analysis to the nonprofit sector. As the leading charity evaluator in the United States, it draws more website traffic than all other charity rating organizations combined.

More than 80 cents of every dollar donated to HHF directly benefits its research efforts towards a cure for hearing loss and tinnitus. Please consider making a gift today. Imagine the day when HHF finds a cure... you'll be able to say you helped made it possible!

HHF reports to the Internal Revenue Service using form 990 under the tax identification number of 13-1882107. HHF is a 501(c)(3) tax-exempt corporation. All donations to HHF are tax-deductible. 

Do Airplanes Trigger Tinnitus?

By Shari Eberts

I am lucky enough to have mostly mild tinnitus. Sometimes I have flare-ups and lately I have been experiencing a day of tinnitus after any air travel. This is a problem for me since I love to travel, and most of the places I like to travel to require an airplane ride. So what’s a weary hard-of-hearing traveler to do? It became clear to me that proper ear protection on the airplane is key.

My post-airplane tinnitus flare-ups have been occurring for the last several months and are usually accompanied by a reduced ability to hear. Even for someone with typical-hearing, it can be a challenge getting off the plane at a new destination, navigating the baggage claim, the rental car agency, and perhaps customs, all with two children in tow. But with a tinnitus flare-up and reduced hearing, it is even more challenging.

For me, I believe the issue is the sustained level of noise on the airplane; according to my iPhone decibel reader app, the interior of a plane is very loud—anywhere from 80 to 95 decibels, depending on the flight. Once in the air, the sound is like white noise and is easy to forget about or ignore, but it is constant, and can be damaging to our hearing. The rule of thumb is that prolonged exposure to any noise at or above 85 decibels can cause gradual hearing loss—and that damage can be permanent.

Here are some workarounds that I have found; I hope they work for you as they do for me:

1. When I get on the plane I shut my hearing aids off, so they act as earplugs. This can be a challenge if I need to communicate during the flight because almost all sound is blocked, preventing me from hearing. While sometimes I must turn them on, I try to keep my aids off for the entire flight, from prior to takeoff until we have reached the gate.
   

2. I try to reserve a seat on the aisle and as far away from the engines as possible. Sometimes this is not possible without paying extra for a special seat, but when possible, I do so.
   

3. I wear a hooded sweatshirt or jacket on the plane for an additional barrier to the noise. It helps prevent the tinnitus and the effect of reduced hearing.

These activities have helped a little bit, but have not fully eliminated the issue. I am still searching for solutions until there is a cure. Please share your tips with us in the comment box below.

This post originally appeared on the blog Living With Hearing Loss on March 25, 2015. The author, Shari Eberts, is the chair of HHF's Board of Directors.

Running with only one goal

By Claire Schultz

I am running this race with one goal in mind:  To raise as much money as possible and accelerate the pace of Hearing Health Foundation's research that will lead to a cure for hearing loss and tinnitus (loud ringing in the ears) in our lifetime.

I decided to take on this enormous challenge of mental and physical endurance with just five weeks to go until the race. A bit daunting, yes. But it is for a good reason.  When I joined Hearing Health Foundation (HHF) back in April,  people were signing up to run on the HHF team to raise money for our mission.  I was told we had one spot remaining and could not fathom that HHF might not take full advantage of this opportunity to raise money to fund our research consortium of leading scientists who are working collaboratively toward a cure.   So, I made the commitment.  I will run the 26.2 miles throughout NYC, and I will cross that finish line with a smile and, hopefully, with your support!   

I am doing this for the people who I know personally who live every day with the challenges of hearing loss.  I he learned from them just how hard it is to live life in a world of silence.  There are 50 million women, men, teens, and children in the U.S. who live each day without their hearing. Noise Induced Hearing Loss (NIHL) and tinnitus are the top two service-connected disabilities among US troops.

You can support me and my goal to raise money for the Hearing Health Foundation. With your help we will make great strides toward a cure for all those people living with hearing loss and tinnitus.

Please go here to donate and those of you who live in and around NYC, come out on November 2nd and cheer me on. 

The HRP's Andy Groves, Ph.D. and HHF Board member Nancy M. Williams to Speak at HLAA Convention

By Tara Guastella

If you are headed to Austin for the Annual Hearing Loss Association of America (HLAA) Convention at the end of June, make sure to stop by Andy Groves, Ph.D.’s workshop on Friday, June 27, at 1:30pm.

Andy Groves, Ph.D.

Baylor College of Medicine

Dr. Groves will be giving a presentation on the Hearing Restoration Project (HRP) and how the power of collaboration is expediting the road to a cure for hearing loss and tinnitus. Chickens, fish, and most non-mammals have a remarkable ability to naturally restore damaged inner ear hair cells (damage or death of these cells is what causes hearing loss). The HRP is working to identify how we can translate this process, known as hair cell regeneration, to humans to develop a biologic cure for hearing loss and tinnitus.

The HRP scientists are working collaboratively sharing ideas, data, and resources to shorten the timeline to a cure. During our last monthly conference call with the consortium, an HRP scientist was presenting initial data on a series of experiments he is conducting. After feedback from other consortium members, he will now approach the experiment in a more beneficial way with greater impact to the research process. This experience highlighted the power of many minds over one.

Hear more about the HRP and the exciting research advancements at Dr. Groves’s workshop on Friday. Materials and information on the HRP will be available for attendees so don’t forget to pick up more information while you’re there.

HHF Board member, Nancy M. Williams, pianist and hearing loss advocate, will also be presenting at the HLAA Convention. She will share her story of reclaiming the piano to help participants tap into their passions.

When Williams reclaimed her passion for the piano after a 25-year hiatus, she came to terms with her hearing loss—and pursuing her passion radiated out to other aspects of her life. Ms. Williams will share her story in the “Finding Your Calling... Despite a Hearing Loss" workshop on Saturday, June 28 at 8:45am.

Be sure to stop by both exciting sessions!

HHF's National Junior Board Raises Over $60,000 at 2nd Annual A Summer Soiree Event

By Tara Guastella

HHF Board Chair Shari Eberts presents Partner for Hearing Health award to Regal's Chris Chromey-Marquis

This past Monday night, HHF’s National Junior Board hosted its second annual “A Summer Soiree” event to benefit a cure for hearing loss and tinnitus. Held at the restaurant Ainsworth Park in New York City, nearly 200 attendees enjoyed cocktails, hors d’oeuvres, a silent auction, raffles, and a fun photo booth. The event raised more than $60,000, a portion of which will be allocated to naming an Emerging Research Grant.

Regal Entertainment Group was presented with the annual Partner for Hearing Health Award for its commitment to people living with hearing impairment. Regal is dedicated to providing solutions for hearing impaired movie-goers and showcased a pair of newly released closed captioning glasses at the event.

HHF CEO Claire Schultz provided remarks at the event and shared her enthusiastic support of the Junior Board members. “It was so encouraging to see such a fantastic turnout at the Soiree and the interest in our work to cure hearing loss and tinnitus,” says Schultz. “I am thrilled to continue working with the Junior Board to further our mission.”

ACS Customs, a provider of custom-fit hearing protection and in-ear monitors for musicians, was also present and provided custom earmolds for attendees.

National Junior Board President Michael Kolodny also spoke before the crowd. “Hearing research is very important to my family since my daughter was born with bilateral hearing loss and currently wears cochlear implants,” he says. “I am so encouraged by the groundbreaking research that HHF funds and I am excited to support the cause of preventing and curing hearing loss and tinnitus.”

HHF appreciates the support from Regal as well as additional event sponsors UBS, Advanced Bionics, Legendary Pictures, Macquarie Capital, ACS, Blue Moon, and DASHA Wellness.

View more event photos on our Facebook page.

Boston Marathon Injuries

By Yishane Lee

Last year, Dave Fortier ran the Boston Marathon in honor of a friend who has leukemia. He experienced up close the two bomb blasts that forever altered the event, becoming one of the nearly 300 people who were injured. A piece of shrapnel became embedded in his right foot, and the immediate ringing in the ears he experienced is now permanent.

Fortier’s foot healed quickly and he was able to race the New York City Marathon seven months later, again to raise funds for leukemia research. But while supporting his friend will always be a priority, Fortier now has a personal interest in promoting the search for a cure for hearing loss and tinnitus. “On long runs I think about things I want to do, and after finishing Boston again this year, my first thought has been to take care of my hearing,” says Fortier, who lives in Newburyport, Mass. “I’m very happy to be supporting Hearing Health Foundation and the search for a cure.”

Fortier, 49, and members of a Boston Marathon survivors support group are running the New Hampshire Reach the Beach Relay in September. The race spans 200 miles and 24 hours, with each member of a 12-person team taking separate legs—including during the middle of the night—totaling nearly 17 miles each.

“Before this year’s Boston Marathon, everybody in this survivor community felt a lot of unity. We had 28 people running the race, and many were first-time marathoners like Chris Campbell,” Fortier says. “I could really see we all felt a sense of belonging, and one of my biggest fears was that after the finish line this feeling would end for all of us. So we quietly went online and registered for Reach the Beach, and when someone asked, ‘Gosh, what do we do next?’ we had an answer—I said, ‘Well guys, we’ve got something for you, if you’re interested—I signed us all up for this race.’”

Fortier says they easily filled one 12-person team, and the personal investment in finding a cure affects several who are running.

“If you see the videos and photos of when the first explosion happens, I’m the guy with a black hat and black shorts who is right behind the gentleman who falls,” he says. “I’m reaching up and holding the side of my head. The sound—it felt like someone hit me with a brick. I actually thought someone behind me had cuffed my ear with a fist. I just remember that pain. The ringing happened instantaneously.”

He adds, “The ringing today is as loud as it was that day. I’ve learned to suppress it a little bit, but when I start talking about it and thinking about it, I can hear it. It’s ever present.”

Although his hearing loss in his left ear, which was facing the first blast, is so far mild, Fortier has been taking steps to compensate. “Now I tell people when I’m first meeting them that I will be leaning toward them to hear better, so they don’t think I’m getting in their personal space for no reason. I’ve also learned to look at the speaker’s lips for clues,” he says.

At night, Fortier uses a combination of white noise and low-volume talk radio to tamp down the tinnitus. “But I’m lucky if I get three solid hours a night. If something wakes me up—like the dog needing to go out at 3:30 a.m.—well, then, I’m up for the day.”

“My injuries were so minor compared with everyone else, but while the stitches in my foot are long gone, for me hearing is the bigger issue for sure,” he says. Fortier is excited and encouraged by the progress of the Hearing Restoration Project (HRP), including the groundbreaking regeneration of inner ear hair cells in adult mice by Albert Edge, Ph.D., an HRP consortium member at Massachusetts Eye and Ear Infirmary, Harvard Medical School.

Unlike other species, such as birds and fish, mammals lose their hearing permanently once inner ear hair cells are damaged by, for instance, a sudden loud noise. The HRP’s goal is to translate the ability of birds and fish to naturally regenerate hair cells to mammals, including humans.

Make Your Summer Fun for a Good Cause: Fundraise to Cure Hearing Loss & Tinnitus

By Tara Guastella

Temperatures are heating up, beaches are now open, the smell of grilling is in the air, and schools will soon be out for summer vacation. This is one of my favorite times of year.

If you have plans for a get together this summer, did you know you can turn your summer fun into a good cause? Well, you can! Whether you’re holding a pool party, car wash, barbecue, or any other type of event, you can turn your occasion into a fundraiser for Hearing Health Foundation (HHF) to support a cure hearing loss and tinnitus.

You can create your fundraiser through our online fundraising website that was specifically designed with you in mind. Once you register, you’ll be able to personalize your giving page with a photo, story about why you are fundraising for HHF, and fundraising goal. You’ll then be able to email family, friends, colleagues, and members of your community directly through our website to encourage them to attend the event and support the cause. You can share your fundraising on social media like Facebook and Twitter to encourage your social network to get involved, too. Finally, track your fundraising progress with your own personal thermometer that will increase with each new donation you receive.

The team at HHF is here to help with your event. We can provide you with written materials (such as complimentary copies of Hearing Health magazine and brochures on a cure hearing loss and tinnitus), earplugs, gift bags, and bracelets. We are also happy to answer any questions you may have about hosting a fundraising event or about using our fundraising website. If you’ve never done anything like this before, don’t let that stop you! We are happy to be your partner in raising funds for a cure for hearing loss and tinnitus.

If you don’t have any events planned this summer, here are a few ideas for you to consider:

• Pool party

• Barbecue

• Clam bake

• Bake sale

• Car wash

• Beach volleyball tournament

• Golf tournament

• Baseball tournament

• Bike race

• Running race

• Obstacle course race (e.g., Spartan race, Warrior Dash, Tough Mudder)

• Birthday, anniversary, wedding, bar/bat mitzvah, Sweet 16 (you can ask for donations in lieu of gifts)

See more ideas and examples of past fundraising events and get started today!

What Does a Chicken Have to Do with Hearing Loss?

http://aubankaitis.com/2014/05/14/chicken-and-hearing-loss/

What would you think if someone told you that a baby chick holds the cure for hearing loss? One of the keys to restoring normal hearing in humans is cochlear hair cell regeneration, something that most animals other than mammals, including chickens, can do.  The Hearing Health Foundation recently launched a new public service announcement (PSA) called “Chirp the News” which features a baby chick with hearing loss who goes on to live a happy, normal-hearing life. After viewing it, my curiosity was piqued. I had an opportunity to ask Shari Eberts, Chairman of the HHF’s Board of Directors, a couple of questions and wanted to share what I learned.

Question: For those that are not familiar with your organization, what is the Hearing Health Foundation and/or what is the Foundation’s mission?

Hearing Health Foundation (HHF) is the largest private funder of hearing research, with a mission to prevent and cure hearing loss and tinnitus through groundbreaking research. Since 1958 HHF has given away millions of dollars to hearing and balance research, including work that led to cochlear implant technology and now through the Hearing Restoration Project is working on a cure for hearing loss and tinnitus. Hearing Health Foundation also publishes Hearing Health magazine, a free consumer resource on hearing loss and related technology, research, and products.

Question: Shari, it is my understanding that you acquired a hearing loss in your late 20′s.  Can you tell me a little bit about how your hearing loss was identified, the cause of your hearing loss, and how it has impacted your personal and professional lives?  

I first noticed my hearing loss in business school. Students were participating in class, and I would sometimes miss their comments, particularly the funny ones that were made almost as an aside. My father and my grandmother both had a hearing loss, so I figured I should get tested. It turns out that I had a mild hearing loss in both ears. The loss is genetic and is centered in the mid-range or speech frequencies. Luckily, my high pitch hearing is almost perfect. My loss has gotten progressively worse each year since business school, but I am able to manage it with hearing aids and by advocating for myself. At first, I didn’t want to admit that I had a hearing loss, and I hid it from others, but eventually I began to realize how much better my life could be if I used my hearing aids, and I began wearing them all the time. I am glad that I do.

As someone who lives with hearing loss everyday, I am personally thrilled with the prospects for a cure. Life with hearing loss can be frustrating.  Sometimes you miss the joke when everyone else is laughing and sometimes you miss important information because you don’t hear it. Supportive family and friends can make living with hearing loss easier, but a genuine cure would be life changing. After having met and worked with our consortium scientists for these past two years, I am confident that we will have a cure in my lifetime. I am counting the days.

Question: Knowing that you acquired a hearing loss in your late 20′s, it makes sense that you would be passionate about educating people about hearing loss and learning about various research focusing on a cure. With so many different organizations dedicated to hearing loss, what made you specifically gravitate toward Hearing Health Foundation? What makes this organization so unique?

HHF’s approach to research is unique and I believe it will shorten the timeline to a cure. For years, scientific research has been conducted in relative isolation—one researcher or one institution working alone to tackle a major health issue. HHF developed the HRP Consortium model to do things differently. Our HRP scientists work on research projects together, share their unpublished data and tools, and collaborate on the development and refinement of the HRP’s strategic research plan. The group meets bi-annually in person, monthly by conference call, and communicates frequently by email. This continual dialogue is helping to eliminate repetitive work across the team, saving time and research dollars, and most importantly, accelerating the timetable to a cure.

Our HRP Consortium is the dream team of hair cell regeneration, comprising the best auditory scientists at leading institutions worldwide such as Harvard and Stanford. With more than 200 years of combined experience in hearing research, the HRP Consortium publishes widely (over 400 published papers among them) and have well established labs (receiving over 600 NIH grants combined). We have every confidence we have the right team in place, and the right model to accelerate the timeline to a cure.

Question: The Hearing Health Foundation was established in 1958 and had been seeking donations from the public to help fund “groundbreaking research” for the prevention of and cure for hearing loss. Can you provide a historical synopsis of some of the more significant research achieved by the Foundation since its inception?

HHF’s founder, Collette Ramsey Baker, was steadfast in her support of funding for new technologies and treatments for hearing loss. For example, back in the 1960s, HHF began funding research into cochlear implant technology. HHF’s founder, Collette Ramsey Baker, prevailed despite objections and doubts from supporters that she was wasting money. Cochlear implants have proven to be a valuable treatment option for people with profound hearing loss, benefiting 125,000 people in the U.S. and 300,000 people worldwide. HHF has also research that led to the development of many of today’s standard treatments for otosclerosis (abnormal bone growth in the ear) and ear infections.   In the 1990s, HHF was a leader in advocating for Universal Newborn Hearing Screening legislation, which increased testing from 5% of newborns to 94% by 2007. In 2011, HHF launched our most important project yet, the Hearing Restoration Project (HRP),  which aims to discover a biological cure for hearing loss and tinnitus.

Question: What research is the Foundation currently working on that is anticipated to have a significant and/or practical impact on hearing loss prevention and/or cure within the next 10 years?

HHF officially launched its Hearing Restoration Project (HRP) in 2011 and is currently funding 5 projects from its consortium scientists, but the initial discovery that led to the HRP came many years before. Many types of hearing loss result from damage to the delicate hair cells of the inner ear. Humans can’t regrow these cells—but in a game-changing breakthrough in 1987, HHF-funded scientists discovered that birds can. While studying how drugs that are known to cause hearing damage affect the tiny sensory cells in the ear, these scientists needed to permanently damage a chicken’s hair cells. For 10 days, research assistants administered a common antibiotic, known to cause hearing loss, to laboratory chickens. On day 11 many of the hair cells were lost and a few days later, even more were lost. Surprisingly, when the scientists looked three weeks later, almost all the hair cells had returned.  They didn’t believe these results so they did the experiment again and again. Sure enough, chickens can naturally regenerate their inner ear hair cells, restoring their hearing after damage.

The amazing thing is that regeneration happens naturally and very robustly in almost all animals – mammals are the exception. This makes HHF and the researchers confident that we will find a way to stimulate this regeneration in mammals, including humans.

The HRP consortium of scientists has developed a strategic research plan to develop a cure for hearing loss and tinnitus in 10 years. This three-phase plan starts with discovery research and culminates in clinical trials. The plan, developed specifically by the HRP scientists and updated to incorporate new findings and approaches, is a living document meant to guide but not limit the work. Relevance to this strategic plan is one of the criteria for a project to receive HRP funding.

The HRP is currently in Phase I of its strategic research plan (years 1-5). This first phase focuses on searching for the genes or series of genes that trigger natural regeneration of hair cells in animals such as birds and zebrafish. This phase will also examine which genes in mammals prevent the natural regeneration of hair cells. Finally, Phase I will determine the types of cells in mammals’ ears that could serve as available targets for regeneration therapies. Phase II (years 3-8) starts with the residual cells that remain in a mammal’s inner ear after hearing loss and uses the genes identified in Phase I to trigger hair cell regeneration. In Phase III (years 8-10), the HRP Consortium will partner with a pharmaceutical or other company to develop drugs that mimic the identified genes, resulting in a regenerative therapy.

Question: How can audiologists and other hearing health care providers get involved with the Hearing Health Foundation?

HHF is always eager to partner with hearing health care providers! In fact, we have developed a brochure specifically for use by hearing health care providers that includes important information for their patients about how hearing works, the types of hearing loss, and common treatment solutions. It also lets patients know about the resources HHF can offer, like its free quarterly magazine. Hearing Health Magazine is the award-winning leading consumer publication on hearing loss filled with the latest on research breakthroughs, strategies to manage hearing loss, personal stories, hearing technologies and products and features on seniors, pediatrics, parents, musicians, veterans and more!   Please feel free to contact us at info@hhf.org if you are a hearing health care professional and would like copies of our patient brochure or magazine.

Question: How can the general public support the mission and goals of the Hearing Health Foundation?

There are lots of ways for people to learn more about HHF and help support our research for a cure for hearing loss and tinnitus.

1. Visit our website to learn more

2. Stay up to date on all the latest news by liking us on Facebook and following us on Twitter

3. Sign up for our informative monthly e-newsletter

4. Subscribe to Hearing Health Magazine, our award-winning leading consumer publication on hearing loss. Get the latest on research breakthroughs, strategies to manage hearing loss, personal stories, hearing technologies and products, and features on seniors, pediatrics, veterans, musicians and more.

5. Inspire others by sharing your personal story and draw comfort from the stories of others

6. Create a fundraising event or giving page

7. Make a tribute gift to honor a loved one with hearing loss or a favorite audiologist

8. Support our work with a tax-deductible donation

Shari Eberts is Chairman of the Board of Directors at the Hearing Health Foundation, an organization whose mission is to prevent and cure hearing loss and tinnitus via collaborative, groundbreaking research. She received her BS from Duke University in 1990 and MBA from the Harvard Business School in 1995. Previously employed by Goldman Sachs and McKinsey & Company, Shari spent 13 years at J.P. Morgan in the capacity of a senior equity analyst (broadlines retail) and, most recently as Associate Director of U.S. Equity Research.  This mom of two and former Wall-Streeter joined HHR in 2010 and has committed herself to supporting the search for a cure for hearing loss and tinnitus.

This Better Hearing & Speech Month, New HRP Research Projects Commence

By Tara Guastella

In conjunction with Better Hearing & Speech month this May, I'm excited to share that HHF is funding, for the third consecutive year, new research grants for our Hearing Restoration Project (HRP) consortium. This year is exciting as our HRP scientists are finishing up the first of three phases of the Strategic Research Plan. This plan defines our road-map to clinical trials for a cure for hearing loss and tinnitus within a decade.

Many types of hearing loss result from damage to the delicate hair cells of the inner ear. Humans can't regenerate these cells-but in a game-changing breakthrough in 1987, HHF-funded scientists discovered that birds can. Over the last several years, the HRP scientists have produced new genomic datasets from fish and birds, which show regeneration, and mouse, which does not; these datasets now allow us to take the next steps in understanding which genes promote regeneration in some animals and which genes block it in others.

“The 2014 funded projects will continue to move us closer to our goal of inducing hair-cell regeneration in people, to produce a cure for hearing loss and tinnitus," shares Peter G. Barr-Gillespie, Ph.D., director of the HRP consortium. "I am incredibly pleased with the outcome of the work the HRP consortium members have been conducting over the last several years.”

We are renewing three projects from previous years as well as initiating four new projects, each moving us closer to a cure. There are also four new projects that have commenced on May 1. Here are the details about the new projects:

Led by Andy Groves, Ph.D., Tatjana Piotrowski, Ph.D., and Jennifer Stone, Ph.D., one of the new projects is focusing on bioinformatic analysis of genetic data collected throughout Phase I. Bioinformatics is a set of sophisticated computational tools that will allow us to compare genetic data from zebrafish, chickens, and mice. Since we know that zebrafish and chickens spontaneously regenerate their inner ear hair cells, we can compare their genetic data to that of mice, which like mammals do not regenerate hair cells. Once we know what genes, or series of genes (known as pathways), trigger regeneration in zebrafish and chickens, and which inhibit it in mice, we will have better targets for drug therapies that may be able to induce regeneration in humans.

Another new project building off of work started in Phase I is analyzing the inner ears of chickens. Chickens have a remarkable ability to regrow hair cells once they are damaged. The consortium members involved—Stefan Heller, Ph.D., Michael Lovett, Ph.D., Jennifer Stone, Ph.D., and Mark Warchol, Ph.D.—are using newly developed techniques to study how supporting cells react when neighboring hair cells die and which signaling pathways are activated or deactivated. They are also are determining if this new technique, known as single cell transcript analysis, can be used more broadly in analyzing regenerative capabilities.

Edwin Rubel, Ph.D., who is also known as the co-founder of hair cell regeneration in chickens, is working on the characterization of a mouse system in which the inner ear hair cells can be reproducibly removed from the inner ear without doing damage to other components of the inner ear. Such a "model system" would allow the systematic study of hair cell regeneration at any age and in live animals.

Finally, Alain Dabdoub, Ph.D. and Albert Edge, Ph.D. are collaborating on a project studying the signaling molecules in the Wnt pathway to better understand its role in regeneration. Wnt signaling has been shown to play a major role in stem cell biology, cell proliferation, and cell fate determination.

“As a person living with hearing loss, I am thrilled with the progress that the HRP consortium is making,” says Shari Eberts, the chairman of HHF’s board of directors. “We are funding the best hearing scientists, conducting groundbreaking research, and are on track to see a cure for hearing loss and tinnitus within a decade.”

Read more about all of the currently funded HRP projects and updates on progress from past research as well.

Boston Marathon Bombing Inspires Family to Run to Cure Hearing Loss and Tinnitus

By Tara Guastella

Last April 15 was a life-changing day for the Campbell family—as it was for many who attended one of the greatest annual sporting events: the Boston Marathon. This year, the Campbell family is not only running their first ever Boston marathon but fundraising to cure for hearing loss and tinnitus. We wanted to share their story with you and hope you'll join us in supporting their marathon run.

Out of the 264 people injured on the day of the Boston Marathon bombing, the Massachusetts Office of Victim Assistance (MOVA) now estimates that at least 150 are experiencing hearing loss or tinnitus.

Jean Campbell is one those people, and this is her and her family’s story.

The days preceding the big race, a friend from Atlanta who was running the race stayed at the Campbell home in New Hampshire. Early the morning of April 15, Jean’s husband Christopher, his wife Jean, and their three sons Corey, Trevor, and Mitchell headed to Boston to watch the friend and several others run the race. (Corey has a mild hearing loss and Trevor moderate to profound hearing loss. Trevor wears hearing aids.) The family was split into two groups since the sons went to different schools and arrived at the race at different times. Jean and youngest son Mitchell were together and Christopher was with the two older sons, Corey and Trevor.

Chris, Jean, Trevor, Mitchell, and Corey Campbell

The two groups ended up on opposite sides of Hereford and Commonwealth Avenue while watching the race. After their friend Diane ran by, both groups started to head to the finish line on Boylston Street. Jean was busy taking photographs of other runners, and like any teenage son, Mitchell urged his mother to hurry up and the two began to bicker. Mitchell was eager to get to the finish line and starting to get impatient. “If we hadn’t been bickering, we would have been closer to the explosions,” says Jean, referring to the two homemade pressure-cooker bombs that exploded that day.

“That blast felt like a hurricane and immediately, it looked like a war zone,” she says. Jean has a sensorineural hearing loss in both ears, she instinctively leaned her “better ear”, the left one toward the first blast. “I knew immediately my hearing loss had worsened,” she says. As a result of the bombings, she also lost discrimination in both of her ears and her tinnitus worsened.

Jean and Mitchell ran for their lives clinging to one another. Jean immediately knew it was a bomb. “ I felt like we were in a movie,” Jean says. To get off the street, they ran into a Crate & Barrel store. “The very competent staff helped us escape through a back door,” she says. “They were incredibly kind and helpful. It was almost as if they were trained for it.” Jean adds that Mitchell remained very calm and collected throughout the day’s events, even after getting hit with a piece of shrapnel and his existing tinnitus growing much worse.

At the moment the blasts were occurring, Christopher and his two older sons happened to be taking a shortcut through the Sheraton Hotel to get to the finish line more quickly. “I couldn’t hear a thing,” Christopher says. “I didn’t even know the bombs had gone off.” Corey and Trevor were worried and frantic wondering where Jean and Micthell were. Since cell phone service was quickly overwhelmed following the explosions, the family could not contact one another. It wasn’t until 10pm that night—back in New Hampshire—that the family was reunited.

As soon as the blasts happened, Jean knew she had to see her audiologist at Massachusetts Eye and Ear Infirmary as she could not hear out of her right ear. She says she had the fleeting thought of trying to go to the hospital in Boston, but at the time it was unclear whether the entire city was under attack. “I needed to find the rest of my family and get out of there,” she says. Jean has bilateral hearing aids and is in a support group for people injured in the Boston Marathon bombings.

One year later, the Campbell family is running the 2014 Boston Marathon in support of Jean and her recovery. They are fundraising to support Hearing Health Foundation and our search for a cure for hearing loss and tinnitus through the Hearing Restoration Project (HRP). The Campbell family has lived through a traumatic event but since there had been hearing loss in their family, they feel they were slightly better equipped to handle the confusion and depression that can come with sudden hearing loss. “We think educating people about what to expect, and how to cope, is important,” Christopher says.

The Campbells are very encouraged by the strides Hearing Health Foundation and our HRP consortium have made so far toward finding a cure for hearing loss and tinnitus, such as early success with regenerating sensitive inner ear hair cells in adult mice that, in all mammals, once damaged through noise or age lead to permanent hearing loss.

Please join us in supporting the Campbell family as they tackle their first marathon and give hope for a cure within a decade.