The findings suggest that blast injuries cause excessive activation of PARP1, which disrupts the brain’s natural ability to manage stress and inflammation. This reduces the activity of sirtuins, which help regulate cell repair and stress responses.
Brain Inflammation Is a Potential Target to Treat Tinnitus
Shaowen Bao, Ph.D., an associate professor of physiology at the University of Arizona College of Medicine–Tucson, and colleagues are closing in on potential treatments for tinnitus by connecting brain inflammation to tinnitus.