Due to the lack of spontaneous regeneration, the hearing loss caused by hair cell loss is permanent. One way to envision future biological/medical repair of the hair cell-depleted inner ear is to medically induce the generation of new hair cells.
Hearing Health Foundation Names Lisa Goodrich, Ph.D., Scientific Director of the Hearing Restoration Project
Hearing Health Foundation (HHF), the largest nonprofit funder of hearing and balance research in the U.S., announced today the appointment of Lisa Goodrich, Ph.D., of Harvard Medical School to the role of Scientific Director of the Hearing Restoration Project (HRP).
UM School of Medicine Researchers Identify Role of Crucial Protein in Development of New Hair Cells Needed for Hearing
Researchers at the University of Maryland School of Medicine (UMSOM) have conducted a study that has determined the role that a critical protein plays in the development of hair cells. These hair cells are vital for hearing. Some of these cells amplify sounds that come into the ear, and others transform sound waves into electrical signals that travel to the brain.
Erica Patino of Hear2Tell Interviews Timothy Higdon of HHF
In summer 2020, Erica Patino, who lives with a genetic hearing loss, interviewed Hearing Health Foundation (HHF) President & CEO about our research programs and progress toward hearing loss cures. HHF’s focus has always been and remains funding the basic science that propels scientific knowledge forward and comprises the building blocks in the development of new treatments, devices, and approaches. Basic science research is foundational and critical to finding cures for hearing loss.
Hearing Restoration Project Plans Announced for 2020–21
Hearing loss occurs when sensory hair cells of the inner ear (cochlea) are damaged or die. The goal of the Hearing Restoration Project (HRP) is to develop therapeutic methods to convert the cells that remain after damage into new, completely functional sensory hair cells, restoring hearing. We know that in most species—but not mammals, like humans and mice—hair cells robustly regenerate on their own after damage to the auditory system.
Sunnybrook Researchers Have Developed a New Way to Detect Hearing Loss In Blood
In their pre-clinical research, Dr. Dabdoub and Dr. Sahar Mahshid, research associate, have designed a biosensor test to detect otolin-1 and prestin, two unique proteins which can be found circulating in blood and are linked to balance and hearing disorders respectively. The test, which is patent pending, is comparable to a glucose monitor and requires only a drop of blood.
2020-2021 Scientific Grantees Announced
Scientific researchers have, like all of us, faced numerous challenges over the past months of the COVID-19 crisis, but have continued the science throughout, whether in reduced occupancy labs or remote, driven by their dedication to advance knowledge and contribute to the treatment and, ultimately, cure for hearing loss and other hearing and balance disorders. HHF’s donors have shown similar dedication, and HHF is happy to provide research funding to the exceptionally promising projects below.
USC Stem Cell Study Shows When to Quit “Yapping”
It turns out that to hear a person yapping, you need a protein called Yap. Working as part of what is known as the Yap/Tead complex, this important protein sends signals to the hearing organ to attain the correct size during embryonic development, according to a new study published in the Proceedings of the National Academy of the Sciences (PNAS) from the USC Stem Cell laboratory of Neil Segil.
Study Charts Developmental Map of Inner Ear Sound Sensor in Mice
Scientists at the National Institute on Deafness and Other Communication Disorders (NIDCD), part of the National Institutes of Health, and their collaborators analyzed data from 30,000 cells from mouse cochlea, the snail-shaped structure of the inner ear. The results provide insights into the genetic programs that drive the formation of cells important for detecting sounds. The study also sheds light specifically on the underlying cause of hearing loss linked to Ehlers-Danlos syndrome and Loeys-Dietz syndrome.
Data Made Visual
Over the past several years, Hearing Health Foundation (HHF)’s Hearing Restoration Project (HRP) has generated a significant amount of data. Part of the challenge for HRP consortium members, as for many life scientists, comes not only from the amount of data they need to analyze but also the need to examine multi-omic datasets.